Biological Pharmaceutical PSA Nitrogen Generating Plant

Short Description:

Principe of PSA Nitrogen Generator Plant

The main components are nitrogen and oxygen in the air. Select adsorbents with different adsorption selectivity for nitrogen and oxygen and design appropriate process to produce nitrogen by separate nitrogen and oxygen.

Both nitrogen and oxygen have quadrupole moments, and the quadrupole moment of nitrogen is much larger than oxygen. Therefore, the adsorption capacity of oxygen in carbon molecular sieve is much stronger than nitrogen in a certain pressure (the force is strong between oxygen and surface ions of molecular sieve).


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Principe of PSA Nitrogen Generator Plant

The main components are nitrogen and oxygen in the air. Select adsorbents with different adsorption selectivity for nitrogen and oxygen and design appropriate process to produce nitrogen by separate nitrogen and oxygen.
Both nitrogen and oxygen have quadrupole moments, and the quadrupole moment of nitrogen is much larger than oxygen. Therefore, the adsorption capacity of oxygen in carbon molecular sieve is much stronger than nitrogen in a certain pressure (the force is strong between oxygen and surface ions of molecular sieve). When the compressed air passes through the adsorption bed with carbon molecular sieve adsorbent, oxygen is adsorbed, and nitrogen is enriched in the gas phase and flows out of the adsorption bed, then the separation is completed to obtain nitrogen. When the molecular sieve adsorbs oxygen near to saturation, stop air supply and reduce the pressure of the adsorption bed, so that the adsorbed oxygen can be desorbed and the molecular sieve can be regenerated and reused. More than two adsorption beds can be switched in turn to continuously produce nitrogen.

Air Entering
Under a certain pressure, the air compressor presses the air into the transmission pipeline, then removes the impurities such as water, oil and dust through the compressed air purification system. When the compressed air enters the air buffer tank, it will be transported to two adsorption towers.

Adsorption
The air in the storage tank will enter the adsorption tower, and oxygen and carbon dioxide are rapidly adsorbed under pressure. When the adsorption does not reach equilibrium, nitrogen is enriched in the gas phase to form nitrogen products. Then depressurize to atmospheric pressure, and the adsorbent desorbs the adsorbed oxygen and other impurities to achieve reactivation. One tower adsorbs nitrogen and the other tower desorbs and reactive. The two towers work alternately to achieve the purpose of continuous production of high-quality nitrogen.

Air Exiting
When the adsorption process reaches the best time (the adsorption of nitrogen to oxygen is the smallest), open the air outlet valve and output the nitrogen products to the buffer tank.
Pressure Equalization
After the air exiting process is completed, there is still nitrogen mixture with certain pressure purity in the tower that is a pity to release. Therefore, it is directly discharged into another adsorption tower for re-adsorption with the next incoming air. It will end when the pressures of the two towers are equal, so he process is called pressure equalization.

Air Releasing
After the pressure equalization is completed, the gas adsorbed by the molecular sieve in the tower needs to be released to prepare for the next adsorption. The system will automatically open the exhaust valve to return the tower pressure to the initial state, and make the molecular sieve have the ability to adsorb new air again.

Process Flow Diagram

Application of PSA Nitrogen Generator Plant for Biological Pharmaceutical

In order to improve the quality of drugs in the pharmaceutical industry, no matter the production of large infusion, water injection, powder injection, freeze-drying agent and oral liquid preparation, all of them need nitrogen filling process.
Because of the particularity of the industry, the requirements for the cleanliness and purity of nitrogen are very high, which must comply with the provisions of international GMP standards. The parts in contact with drugs or liquid medicine are made of stainless steel and the requirements for sterilization, so that the equipment needs to be made of stainless steel, and the nitrogen outlet is equipped with a sterilization filter device.
Requirements for nitrogen in drug production:
1)The purity of nitrogen is high, which generally needs to reach 99.9% ~ 99.99%. This is the requirement of no oxygen in the national standard;
2)Nitrogen contains no dust and heat source to be used for filling and sealing of injections;
3)Nitrogen can maintain constant pressure supply to ensure the normal operation in the production process.
In the past pharmaceutical industry, most of the nitrogen comes from industrial nitrogen in steel cylinder or standard nitrogen gasified by liquid nitrogen. This kind of industrial nitrogen needs to be transported and loaded, occupies a large area with low safety, and it can not supply gas continuously. But the PSA Nitrogen Generator Plant can continuously provide stable high-purity medicinal nitrogen to save many troubles, and improve the purity and cleanliness of nitrogen to achieve the provisions of international GMP standards.

Synthetic pharmaceutical
Nitrogen can be used as protective gas to fill the chemical drug synthesis reaction, so that the oxygen is isolated, and the chemical reaction can be carried out in a clean environment without side reactions. Therefore, the high-quality products will be obtained. Nitrogen is also used as the gas source to provide power, that protect some liquids or intermediates safely to transport to the designated process.

Biological Pharmaceutical
The sterile medium was isolated from the environment with high-purity nitrogen to achieve high process requirements;

Nitrogen Filling and Potting & Nitrogen Protection and Transportation
In the production process of large volume injections and small volume injections, high purity nitrogen should be used as protective gas to isolate the air to achieve high quality products. During drug packaging, nitrogen is also used as protective gas to prevent drug pollution and oxidation. For the packaging, transportation and protection of pharmaceutical raw materials and drugs, as well as the storage tanks and containers of Western medicine injections, all of them needs the nitrogen protection.

Main Technical Parameters

Nitrogen Flow Rate 3 ~ 3000Nm3/h
Nitrogen Purity 95 ~ 99.999%
Nitrogen Pressure 0.1 ~ 0.8 MPa(Adjustable)
Dew Point -60℃ ~ -45

Model Identifiers of Membrane Separation Nitrogen Generator.

Specification Output(Nm³/h) Effective Gas Consumption (Nm³/min) Inlet DN(mm) Outlet DN(mm)
BNN99.9-20 20 1.38 25 15
BNN99.9-30 30 2.08 32 20
BNN99.9-40 40 2.77 40 20
BNN99.9-50 50 3.47 40 20
BNN99.9-60 60 4.16 40 20
BNN99.9-70 70 4.85 50 20
BNN99.9-80 80 5.53 50 20
BNN99.9-100 100 6.91 50 25
BNN99.9-120 120 8.30 50 25
BNN99.9-150 150 10.37 50 32
BNN99.9-180 180 12.44 65 32
BNN99.9-200 200 13.83 65 32
BNN99.9-250 250 17.28 65 40
BNN99.9-300 300 20.74 80 40
BNN99.99-20 20 1.84 32 15
BNN99.99-30 30 2.76 40 20
BNN99.99-40 40 3.68 40 20
BNN99.99-50 50 4.60 40 20
BNN99.99-60 60 5.52 50 20
BNN99.99-70 70 6.44 50 20
BNN99.99-80 80 7.36 50 25
BNN99.99-100 100 9.20 50 25
BNN99.99-120 120 11.04 65 25
BNN99.99-150 150 13.80 65 32
BNN99.99-180 180 16.56 65 32
BNN99.99-200 200 18.40 65 32
BNN99.99-250 250 23.00 80 40
BNN99.99-300 300 27.60 80 40

Note:
According to requirements of customer (nitrogen flow / purity / pressure, environment, main uses and special requirements), Binuo Mechanics will be customized for non-standard products.

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